THERAPY DOSSIER · th-157535883877

Syngeneic whole-layer olfactory mucosa graft, comprising olfactory epithelium and lamina propria containing olfactory ensheathing cells

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Crush
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01231893 ↗Injury indicationPHASE1unknown

Transplantation of Autologous Olfactory Ensheathing Cells for Complete Human Spinal Cord Injuries

Complete Spinal Cord Injuries

Enrolment: 10 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29713644 ↗2018Mixed findings

The Therapeutic Effects after Transplantation of Whole-Layer Olfactory Mucosa in Rats with Optic Nerve Injury.

RatCrushOther / unspecifiedLewis (inbred, syngeneic donor and recipient)MaleLocal transplantation into the optic nerve lesion sitePieces of whole-layer olfactory mucosa transplanted into th…Acutely, at the time of optic nerve crush

Model: Crush injury of the right optic nerve

Olfactory mucosa transplantation increased retinal ganglion cell survival and axonal growth and raised GAP-43 while lowering retinal GFAP compared with phosphate buffered saline. The full text notes the protective effect on injured neurons is present within two weeks but weakens or disappears by fo…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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