Human Multilineage-differentiating Stress-Enduring Cells Exert Pleiotropic Effects to Ameliorate Acute Lung Ischemia-Reperfusion Injury in a Rat Model.
RatIschaemia-reperfusionOther / unspecifiedSprague-DawleyMaleInjection via the left pulmonary arteryAfter reperfusion, immediately following the two hour warm ischaemic period
Model: Two hour warm ischaemia of the left lung followed by reperfusion
Muse cell treatment gave significantly better PaO2/FiO2 ratio, alveolar-arterial oxygen gradient, lung compliance and histological injury score than mesenchymal stem cells or vehicle, with more efficient homing to the injured lung, reduced alveolar cell apoptosis, increased proliferation and higher…
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