THERAPY DOSSIER · th-72a1bf468722

Human multilineage-differentiating stress-enduring (Muse) cells, isolated from human mesenchymal stem cells by magnetic-activated cell sorting

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07326059 ↗Injury indicationPhase not recordednot yet recruiting

An Observational Study on the Safety and Outcomes of MUSE Stem Cell Therapy in Participants With Traumatic Brain Injury

Traumatic Brain Injury

Enrolment: 10 · Results not recorded

NCT07521384 ↗Injury indicationPhase not recordedenrolling by invitation

Prospective Observational Multi Cohort Study of Intranasal MuSE Cell Derived Exosomes, MuSE Stem Cells, and Combination Therapy

Traumatic Brain Injury · Cerebral Palsy · Stroke · Multiple Sclerosis

Enrolment: 36 · Results not recorded

NCT07645989 ↗Injury indicationPhase not recordedrecruiting

Registry of Outcomes of Dezawa MuseCells

Osteoarthritis · Wound Care · Pain

Enrolment: 5000 · Results not recorded

NCT07511660 ↗Phase not recordedenrolling by invitation

Ultrasound Guided Intra Ovarian Injection of Muse Cells for Reversal of Perimenopausal Ovarian Decline in Women Aged 28-70 Years

Perimenopause · Premature Ovarian Insufficiency · Diminished Ovarian Reserve

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29707971 ↗2018Reported benefit

Human Multilineage-differentiating Stress-Enduring Cells Exert Pleiotropic Effects to Ameliorate Acute Lung Ischemia-Reperfusion Injury in a Rat Model.

RatIschaemia-reperfusionOther / unspecifiedSprague-DawleyMaleInjection via the left pulmonary arteryAfter reperfusion, immediately following the two hour warm ischaemic period

Model: Two hour warm ischaemia of the left lung followed by reperfusion

Muse cell treatment gave significantly better PaO2/FiO2 ratio, alveolar-arterial oxygen gradient, lung compliance and histological injury score than mesenchymal stem cells or vehicle, with more efficient homing to the injured lung, reduced alveolar cell apoptosis, increased proliferation and higher…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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