Cordycepin alleviates lipopolysaccharide-induced acute lung injury via Nrf2/HO-1 pathway.
RatEndotoxin/LPSWistarMaleIntravenous injection1, 10 or 30 mg/kg body weightOne hour after LPS injection
Model: Acute lung injury induced by intravenous lipopolysaccharide (30 mg/kg body weight)
Cordycepin increased HO-1 expression and activity and induced Nrf2 nuclear translocation, reduced superoxide and nitrite/nitrate levels, modulated TNF-alpha, IL-6 and IL-10 secretion via HO-1, and reduced lung tissue inflammation and injury.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.