Evaluation of the Effect of Cordycepin on CD8+ Lymphocytopenia in Patients With Solid Tumors: A Randomized Withdrawal Trial
Solid Cancer · Lymphopenia
Enrolment: 127 · Results not recorded
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Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Solid Cancer · Lymphopenia
Enrolment: 127 · Results not recorded
Refractory TdT-Positive Leukemia
Enrolment: 44 · Results not recorded
Leukemia
Enrolment: 14 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: LPS-induced acute lung injury
Cordycepin blocked LPS-induced airway neutrophilia and inflammatory gene expression in mice, acting as a PARP inhibitor.
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Model: Acute lung injury induced by intravenous lipopolysaccharide (30 mg/kg body weight)
Cordycepin increased HO-1 expression and activity and induced Nrf2 nuclear translocation, reduced superoxide and nitrite/nitrate levels, modulated TNF-alpha, IL-6 and IL-10 secretion via HO-1, and reduced lung tissue inflammation and injury.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.