Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-κB and MAPK signaling pathway.

Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-κB and MAPK signaling pathway.

Model: Weight-drop model of traumatic brain injury

Metformin improved neurological deficit and reduced cerebral oedema and neuronal apoptosis after traumatic brain injury, inhibited microglial activation and lowered TNF-alpha, IL-1beta and IL-6, with reduced NF-kappaB p65 nuclear translocation and ERK1/2 and p38 MAPK phosphorylation.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.