Changes in the hippocampal and peripheral phospholipid profiles are associated with neurodegeneration hallmarks in a long-term global cerebral ischemia model: Attenuation by Linalool.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarOral25 mg/kg in vivo; 0.1 micromolar in vitroAfter global cerebral ischaemia
Model: In vivo global cerebral ischaemia in Wistar rats, with an in vitro glutamate excitotoxicity model (125 micromolar glutamate)
Oral linalool produced faster neurological recovery and better motor and cognitive performance than untreated ischaemic animals, with reduced astrogliosis, microgliosis and COX-2, decreased hippocampal 24:0 free fatty acid, and prevention of the altered hippocampal and serum phospholipid profiles.…
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