Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Ischaemia-reperfusion · Radiation · Endotoxin/LPS
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 3
3 studies reported at therapy level; 3 evidence entries itemised.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarOral25 mg/kg in vivo; 0.1 micromolar in vitroAfter global cerebral ischaemia
Model: In vivo global cerebral ischaemia in Wistar rats, with an in vitro glutamate excitotoxicity model (125 micromolar glutamate)
Oral linalool produced faster neurological recovery and better motor and cognitive performance than untreated ischaemic animals, with reduced astrogliosis, microgliosis and COX-2, decreased hippocampal 24:0 free fatty acid, and prevention of the altered hippocampal and serum phospholipid profiles.…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
MouseRadiationSwiss albinoTopical and intraperitoneal (studied as separate treatment arms)Administered before each UVB exposure
Model: Acute UVB (280-320 nm) irradiation of skin at 180 mJ/cm2 causing inflammation, and chronic UVB exposure thrice weekly for 30 weeks causing photocarcinogenesis
Topical or intraperitoneal linalool prevented acute UVB-induced hyperplasia, oedema, lipid peroxidation and antioxidant depletion and blocked COX-2 and ODC overexpression. In the chronic 30-week model linalool significantly reduced expression of proliferative and inflammatory markers and decreased…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
MouseEndotoxin/LPSBALB/cMale
Model: Lipopolysaccharide-induced acute lung injury, with parallel in vitro lipopolysaccharide-stimulated RAW 264.7 macrophage experiments
Linalool attenuated lipopolysaccharide-induced tumour necrosis factor alpha and interleukin-6 production both in vitro and in vivo, blocked phosphorylation of IkB alpha and mitogen-activated protein kinases in stimulated macrophages, and attenuated lung histopathological changes in mice.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
