HDAC inhibition helps post-MI healing by modulating macrophage polarization.
MouseIschaemia-reperfusionCardiacCD1MaleIntraperitoneal injection for the first dose, then oral via drinking water100 mg/kg for the first dose; subsequent doses delivered vi…First dose immediately after coronary ligation surgery
Model: Permanent ligation of the left anterior descending coronary artery to produce myocardial infarction
SAHA did not alter early recruitment of leukocytes, monocytes or CD86-positive inflammatory macrophages through day 3, but reduced CD45/CD11b and CD86 populations at days 5 to 7 and markedly increased CD206-positive reparative macrophages from day 1 through day 5. M2 markers were up-regulated at da…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.