Drug · Pan-histone deacetylase (HDAC) inhibitor; INHIBITOR action at HDAC1, HDAC2, HDAC3 and HDAC6
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Recurrent Non-small Cell Lung Cancer · Stage IIIB Non-small Cell Lung Cancer · Stage IV Non-small Cell Lung Cancer
Enrolment: 94 · Results not recorded
Brain Metastasis
Enrolment: 4 · Results not recorded
Uveal Melanoma · Recurrent Melanoma · Stage IV Melanoma
Enrolment: 32 · Results not recorded
HIV Infections
Enrolment: 31 · Results not recorded
Lymphoma
Enrolment: 17 · Results not recorded
Myelodysplastic Syndrome · Acute Myeloid Leukemia · Chronic Myelomonocytic Leukemia
Enrolment: 135 · Results not recorded
Pancreatic Cancer · Periampullary Adenocarcinoma
Enrolment: 21 · Results not recorded
Non-Small-Cell Lung Carcinoma
Enrolment: 12 · Results not recorded
Prostate Cancer · Adenocarcinoma of the Prostate · Hormone-resistant Prostate Cancer
Enrolment: 13 · Results not recorded
Leukemia
Enrolment: 5 · Results not recorded
Malignant Solid Tumour
Enrolment: 30 · Results not recorded
Breast Cancer
Enrolment: 17 · Results not recorded
Advanced Cancer Relapsed · Advanced Cancer Refractory
Enrolment: 25 · Results not recorded
HIV Infection · Recurrent Non-small Cell Lung Cancer · Stage IV Breast Cancer
Enrolment: 17 · Results not recorded
Lymphoma
Enrolment: 10 · Results not recorded
Rett Syndrome
Enrolment: 15 · Results not recorded
Non Small Cell Lung Cancer
Enrolment: 21 · Results not recorded
Pruritus
Enrolment: 0 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Experimentally induced spontaneous intracerebral haemorrhage
SAHA-treated mice showed less neurodegeneration and improved neurological outcomes compared with vehicle-treated mice, together with reduced glial activation and lower expression of heme oxygenase-1, supporting a role for epigenetic mechanisms in neurological injury after intracerebral haemorrhage.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Permanent ligation of the left anterior descending coronary artery to produce myocardial infarction
SAHA did not alter early recruitment of leukocytes, monocytes or CD86-positive inflammatory macrophages through day 3, but reduced CD45/CD11b and CD86 populations at days 5 to 7 and markedly increased CD206-positive reparative macrophages from day 1 through day 5. M2 markers were up-regulated at da…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
