Ursodeoxycholic acid protects against intestinal barrier breakdown by promoting enterocyte migration via EGFR- and COX-2-dependent mechanisms.
MouseEndotoxin/LPS
Model: Lipopolysaccharide-induced acute intestinal barrier injury in mice, with a parallel in vitro epithelial wound-healing assay; EGFR-dominant negative Velvet mice used as a genetic control
UDCA stimulated intestinal epithelial cell migration in vitro and in vivo and protected the intestinal barrier from LPS-induced injury, reducing FITC-dextran leakage into serum. Protection was abolished by COX-2 inhibition with rofecoxib and in EGFR-dominant negative Velvet mice, and UDCA increased…
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