Trial title not recorded
Type 2 Diabetes Mellitus · Chronic Liver Disease
Enrolment: 20 · Results not recorded
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Drug · Bile acid receptor FXR agonist
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Type 2 Diabetes Mellitus · Chronic Liver Disease
Enrolment: 20 · Results not recorded
Choledocholithiasis · Recurrence
Enrolment: 150 · Results not recorded
Primary Sclerosing Cholangitis · Cholestasis
Enrolment: 104 · Results not recorded
Cholecystitis, Acute · Cholecystitis, Chronic
Enrolment: 172 · Results not recorded
Primary Biliary Cholangitis
Enrolment: 37 · Results not recorded
Hepatitis, Autoimmune · Cholangitis · Liver Cirrhosis, Biliary · Cholestasis
Enrolment: 53 · Results not recorded
Bone Regeneration
Enrolment: 26 · Results not recorded
Cholestasis of Pregnancy
Enrolment: 50 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Lipopolysaccharide-induced acute intestinal barrier injury in mice, with a parallel in vitro epithelial wound-healing assay; EGFR-dominant negative Velvet mice used as a genetic control
UDCA stimulated intestinal epithelial cell migration in vitro and in vivo and protected the intestinal barrier from LPS-induced injury, reducing FITC-dextran leakage into serum. Protection was abolished by COX-2 inhibition with rofecoxib and in EGFR-dominant negative Velvet mice, and UDCA increased…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Chenodeoxycholic acid-induced pancreatic ductal injury in isolated intra-interlobular ducts, and acute pancreatitis induced in rats by retrograde intraductal injection of 0.5% chenodeoxycholic acid
Pretreatment with 0.5 mM UDCA for 24 h reduced ATP depletion, mitochondrial injury and cell death caused by 1 mM chenodeoxycholic acid and fully prevented its inhibition of acid-base transport, while oral UDCA at 250 mg/kg markedly reduced the severity of chenodeoxycholic acid-induced acute pancrea…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.