Qingchangligan formula alleviates acute liver injury by attenuating extracellular histone-associated inflammation.
MouseChemical/toxinC57BL/6Male
Model: Concanavalin A-induced acute immune-mediated liver injury in mice, with parallel histone-induced damage in HL-7702 human hepatocytes and an observational clinical arm in acute-on-chronic liver failure patients
QCLGF improved survival in Concanavalin A-treated mice, reduced hepatotoxicity and lowered extracellular histones and associated cytokines, with inhibition of MAPK signalling. QCLGF also prevented histone-induced HL-7702 cell damage, and acute-on-chronic liver failure patients receiving QCLGF in ad…
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.