THERAPY DOSSIER · th-b18f90065824

Qingchangligan formula (QCLGF), a traditional Chinese herbal formula

Nutraceutical · Qingchangligan formula (QCLGF), a traditional Chinese herbal formula.

Evidence & regulatory context

Mechanism: Qingchangligan formula (QCLGF), a traditional Chinese herbal formula.
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29649629 ↗2018Reported benefit

Qingchangligan formula alleviates acute liver injury by attenuating extracellular histone-associated inflammation.

MouseChemical/toxinC57BL/6Male

Model: Concanavalin A-induced acute immune-mediated liver injury in mice, with parallel histone-induced damage in HL-7702 human hepatocytes and an observational clinical arm in acute-on-chronic liver failure patients

QCLGF improved survival in Concanavalin A-treated mice, reduced hepatotoxicity and lowered extracellular histones and associated cytokines, with inhibition of MAPK signalling. QCLGF also prevented histone-induced HL-7702 cell damage, and acute-on-chronic liver failure patients receiving QCLGF in ad…

Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.

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