Traumatic Brain Injury-Induced Acute Lung Injury: Evidence for Activation and Inhibition of a Neural-Respiratory-Inflammasome Axis.
MouseTBIControlled cortical impactC57BL/6MaleAfter adoptive transfer of extracellular vesicles isolated from TBI-injured mice
Model: Controlled cortical impact traumatic brain injury with secondary acute lung injury, plus adoptive transfer of extracellular vesicles isolated from injured mice into recipient mice
Controlled cortical impact released extracellular vesicles containing inflammasome proteins into serum that targeted the lung and caused acute lung injury. Both enoxaparin and an anti-ASC monoclonal antibody significantly inhibited inflammasome activation in recipient lungs and improved acute lung…
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