A Single Dose of Atorvastatin Applied Acutely after Spinal Cord Injury Suppresses Inflammation, Apoptosis, and Promotes Axon Outgrowth, Which Might Be Essential for Favorable Functional Outcome.
RatSpinal cord injuryCompressionWistarFemalen = 48 rats in total: control n = 6; SCI 24 h n = 12; SCI six w…Intraperitoneal5 mg/kgImmediately after the compression injury
Model: Th9 laminectomy followed by compression spinal cord injury using a 40 g weight for 15 min under isoflurane anaesthesia
A single 5 mg/kg intraperitoneal dose of atorvastatin given immediately after Th9 compression reduced serum IL-1beta at 4 h from 490.3 plus or minus 82 pg/mL to 42.8 plus or minus 7.3 pg/mL, and reduced ED-1 positive macrophage infiltration at 24 h from 293 plus or minus 22.9 to 145 plus or minus 4…
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