Effect of Atorvastatin Versus Rosuvastatin Intensive Statin Regimens on Chinese Elderly Patients Undergoing Percutaneous Coronary Intervention
Focus of Study
Enrolment: 1000 · Results not recorded
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Drug · HMG-CoA reductase inhibitor
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Focus of Study
Enrolment: 1000 · Results not recorded
Dyslipidemias
Enrolment: 242 · Results not recorded
Hypercholesterolemia
Enrolment: 406 · Results not recorded
Hypercholesterolemia
Enrolment: 4875 · Results not recorded
Prostate Cancer
Enrolment: 27 · Results not recorded
HIV
Enrolment: 24 · Results not recorded
Immune Thrombocytopenia
Enrolment: 200 · Results not recorded
Dissecting Aneurysm of Cerebral Artery · Intramural Hematomas · Inflammation Vascular
Enrolment: 40 · Results not recorded
6 studies reported at therapy level; 9 evidence entries itemised.
Model: Experimental rotator cuff (supraspinatus) tear with surgical suture repair
Atorvastatin increased maximal loading by about 30% and stiffness by about 20% versus saline, and by about 33% and 50% versus celecoxib. Celecoxib alone did not affect tendon healing. Effects were blocked by an EP4 selective antagonist.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Th9 laminectomy followed by compression spinal cord injury using a 40 g weight for 15 min under isoflurane anaesthesia
A single 5 mg/kg intraperitoneal dose of atorvastatin given immediately after Th9 compression reduced serum IL-1beta at 4 h from 490.3 plus or minus 82 pg/mL to 42.8 plus or minus 7.3 pg/mL, and reduced ED-1 positive macrophage infiltration at 24 h from 293 plus or minus 22.9 to 145 plus or minus 4…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Controlled cortical impact (eCCI-6.3) via 3.5 mm right-hemisphere craniotomy 2.0 mm posterior and 2.0 mm lateral to bregma, 3 mm flat impactor tip, velocity 4.5 m/s, depth 2 mm, dwell time 200 ms
Atorvastatin at 1 mg/kg/day reduced neuronal apoptosis and neurological deficits, attenuated invasion of T cells, neutrophils and NK cells and pro-inflammatory mediators, increased regulatory T cells and IL-10 and TGF-beta1, and raised the M2 to M1 microglia and macrophage ratio.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Acute 8 mm punch excision wound in the dorsal region under anaesthesia
Lesion areas were significantly reduced in all atorvastatin-treated groups compared with placebo, with increased IRS-1, PI3K, Akt, GSK-3 and IL-10 expression and lower IL-6 and TNF-alpha on days 1, 3 and 7.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Weight-drop contusion spinal cord injury at T10 after single-level laminectomy
Atorvastatin improved locomotor recovery and significantly reduced IL-1 beta, IL-6 and lipid peroxide levels compared with injured controls.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Endotoxin-induced acute lung injury by intraperitoneal LPS 10 mg/kg
Atorvastatin and pravastatin showed anti-inflammatory and antioxidant activity whereas simvastatin did not; all three statins reduced lipid peroxidation and TNF-alpha.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.