Ghrelin therapy mitigates bone marrow injury and splenocytopenia by sustaining circulating G-CSF and KC increases after irradiation combined with wound.
MouseRadiationB6D2F1/JFemalen = n = 6 mice per group per time point; total animal number no…Lateral tail vein injection (intravenous)113 micrograms/kg in a volume of 0.2 mL, three doses24, 48 and 72 h after radiation injury or combined injury
Model: Radiation combined injury: 9.5 Gy whole-body bilateral cobalt-60 gamma-photon irradiation at 0.4 Gy/min, followed within 1 h by a 15 per cent total body surface area dorsal skin wound under isoflurane
Ghrelin given at 113 micrograms/kg intravenously at 24, 48 and 72 h after combined injury mitigated the rise in sternal adipocytes and fall in megakaryocytes, recovered femur bone marrow cell counts on days 1, 7 and 15, recovered total white blood cells on day 3 with neutrophils and monocytes on da…
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