Navy and black bean supplementation attenuates colitis-associated inflammation and colonic epithelial damage.
MouseChemical/toxinC57Bl/6MaleOral, dietaryIsocaloric 20% cooked navy bean or black bean dietPrefeeding for 3 weeks before colitis induction, switched to control basal diet…
Model: Acute colitis induced by dextran sodium sulfate, 2% w/v in drinking water for 5 days followed by 3 days of fresh water
Bean prefeeding attenuated the acute colitis phenotype, lowering colonic and serum inflammatory mediators and inflammatory transcription factor activation, while raising wound repair markers and epithelial barrier gene expression versus basal diet (P<=0.05).
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