PRECLINICAL PUBLICATION · 2018

O-Linked beta-N-Acetylglucosamine Modification of A20 Enhances the Inhibition of NF-kappaB (Nuclear Factor-kappaB) Activation and Elicits Vascular Protection After Acute Endoluminal Arterial Injury.

Rat / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Glucosamine, with the O-linked N-acetylglucosaminidase inhibitor thiamet G in vitro and adenoviral A20 manipulation

PMID 29622561 ↗2018Reported benefit

O-Linked beta-N-Acetylglucosamine Modification of A20 Enhances the Inhibition of NF-kappaB (Nuclear Factor-kappaB) Activation and Elicits Vascular Protection After Acute Endoluminal Arterial Injury.

RatOtherSprague-DawleyMale

Model: Balloon-induced endoluminal carotid arterial injury

Glucosamine markedly inhibited neointimal formation and p65 activation in balloon-injured rat carotid arteries versus vehicle. Adenoviral A20 shRNA abolished this vascular protection, indicating that A20 O-GlcNAcylation is required for the benefit.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.