THERAPY DOSSIER · th-374bf16fe397

Glucosamine, with the O-linked N-acetylglucosaminidase inhibitor thiamet G in vitro and adenoviral A20 manipulation

Nutraceutical · Supplement. Not fully elucidated; may have anti-inflammatory, anti-catabolic and additional effects.

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Supplement. Not fully elucidated; may have anti-inflammatory, anti-catabolic and additional effects.
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: CHEMBL493287 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Chitosamine; Glucosamina; Glucosamine; Mediflex
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05321836 ↗NAcompleted

Effects of Combined Glucosamine/Chondroitin With Structured Physical Therapy Program on Knee Osteoarthritis: A Randomized Control Trial

Knee Osteoarthritis

Enrolment: 30 · Results not recorded

NCT03106584 ↗NAunknown

Marigot's Nutrition Supplement to Improve Symptoms and Physical Function in Mild to Moderate Knee Osteoarthritis Versus Glucosamine Sulphate

Knee Osteoarthritis

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29622561 ↗2018Reported benefit

O-Linked beta-N-Acetylglucosamine Modification of A20 Enhances the Inhibition of NF-kappaB (Nuclear Factor-kappaB) Activation and Elicits Vascular Protection After Acute Endoluminal Arterial Injury.

RatOtherSprague-DawleyMale

Model: Balloon-induced endoluminal carotid arterial injury

Glucosamine markedly inhibited neointimal formation and p65 activation in balloon-injured rat carotid arteries versus vehicle. Adenoviral A20 shRNA abolished this vascular protection, indicating that A20 O-GlcNAcylation is required for the benefit.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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