Dexamethasone Protects Against Tourniquet-Induced Acute Ischemia-Reperfusion Injury in Mouse Hindlimb.
MouseIschaemia-reperfusionLimb / skeletal muscleC57BL/6Malen = n=5 mice per group for contractile force, histology and EPP…Intraperitoneal injection1 mg/kgAdministered at the beginning of reperfusion (i.e., after 3 h of tourniquet isc…
Model: Tourniquet-induced unilateral (left) hindlimb ischemia-reperfusion: orthodontic rubber band tourniquet at the hip joint for 3 h, followed by 24 h reperfusion
Dexamethasone given at the start of reperfusion significantly reduced IL-1beta and TNFalpha expression, decreased leukocyte infiltration, reduced gastrocnemius infarct size (24.8% vs 42.8% in untreated IR) and rupture of the muscle sarcolemma, and improved direct muscle stimulation-induced contract…
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