PebbleAtlas
PEBBLE / ATLAS
Open research access
PRECLINICAL PUBLICATION · 2018

Potential risk of clonally expanded amnion mesenchymal stem cell transplants in contused spinal cords.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 29614703 ↗2018Reported harm

Potential risk of clonally expanded amnion mesenchymal stem cell transplants in contused spinal cords.

RatSpinal cord injuryContusionSprague-DawleyFemaleIntra-parenchymal (intraspinal) injectionAcute injection after SCI; exact time post-injury not specified in abstract

Model: Contusion spinal cord injury (SCI) in rats

Injection of rAM-MSC after SCI did not improve behavioural recovery; BBB scores were significantly reduced compared with vehicle-injected controls over 6 weeks. Injected spinal cords showed abnormal hardening and increased extracellular matrix deposition around and beyond the injury site, with pers…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.