THERAPY DOSSIER · th-b9bd40251b4e

GFP-positive clonally expanded rat amnion mesenchymal stem cell clone (rAM-MSC) derived from E18.5 rat amnion

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07115082 ↗PHASE1/PHASE2recruiting

A Randomized, Open-label, Parallel-controlled Clinical Study of Amniotic Mesenchymal Stem Cells in the Treatment of Premature Ovarian Insufficiency

Premature Ovarian Insufficiency

Enrolment: 50 · Results not recorded

NCT04706312 ↗PHASE1unknown

The Safety and Efficacy Assessment of Human Amniotic Mesenchymal Stem Cells(hAMSCs) Transplantation in Woman With Diminished Ovarian Reserve (DOR)

Diminished Ovarian Response

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29614703 ↗2018Reported harm

Potential risk of clonally expanded amnion mesenchymal stem cell transplants in contused spinal cords.

RatSpinal cord injuryContusionSprague-DawleyFemaleIntra-parenchymal (intraspinal) injectionAcute injection after SCI; exact time post-injury not specified in abstract

Model: Contusion spinal cord injury (SCI) in rats

Injection of rAM-MSC after SCI did not improve behavioural recovery; BBB scores were significantly reduced compared with vehicle-injected controls over 6 weeks. Injected spinal cords showed abnormal hardening and increased extracellular matrix deposition around and beyond the injury site, with pers…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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