Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury.
MouseEndotoxin/LPS
Model: Intratracheal LPS-induced lung injury
Doxycycline produced a partial reduction in LPS-induced heparan sulfate shedding but only a non-significant trend towards decreased alveolar permeability, indicating it was not sufficient to rescue epithelial barrier function after intratracheal LPS-induced lung injury.
Extraction: extract · Supplied extraction confidence: 0.45. Machine-extracted fields require source verification.