The Synthetic Steroid Tibolone Decreases Reactive Gliosis and Neuronal Death in the Cerebral Cortex of Female Mice After a Stab Wound Injury.

The Synthetic Steroid Tibolone Decreases Reactive Gliosis and Neuronal Death in the Cerebral Cortex of Female Mice After a Stab Wound Injury.

Model: Stab wound injury to the cerebral cortex

By 7 days after stab wound brain injury, tibolone reduced the number of GFAP-positive astrocytes, Iba1-positive microglia and reactive-phenotype microglia, and reduced neuronal loss near the wound, compared with vehicle-injected animals.

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