THERAPY DOSSIER · th-7cf428ac4a20

Tibolone

Hormone

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This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: CHEMBL2103774 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Tibolone; Livial; Tibolona; ORG OD 14; ORG-OD 14; NSC-759898
Note: Not recorded

Clinical trials 8

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06117969 ↗PHASE4unknown

Different Therapy Regimens on Menopausal Sleep Disorders

Menopause · Sleep Disorder

Enrolment: 180 · Results not recorded

NCT00431431 ↗PHASE4completed

Tibolone and Raloxifene on Bone Mineral Density in Osteopenic Postmenopausal Women

Osteopenia

Enrolment: 324 · Results not recorded

NCT00735852 ↗PHASE4completed

LHRH Agonist With Livial Add Back Therapy in Chronic Cyclical Pelvic Pain

Endometriosis

Enrolment: 31 · Results not recorded

NCT00408863 ↗PHASE3completed

Tibolone (Org OD14) in Women With Climacteric Symptoms and History of Breast Cancer

Breast Cancer · Climacteric Symptoms

Enrolment: 3148 · Results not recorded

NCT00299364 ↗PHASE3completed

Black Cohosh Vs Tibolone in Patients With Menopausal Symptoms

Menopause

Enrolment: 240 · Results not recorded

NCT00413764 ↗PHASE3completed

Tibolone vs Transdermal Estradiol/Norethisterone on Sexual Desire

Sexual Dysfunction

Enrolment: 358 · Results not recorded

NCT01543399 ↗NAcompleted

Vascular Effect of Tibolone Versus Placebo (Flow-mediated Dilatation)

Menopause

Enrolment: 60 · Results not recorded

NCT01679795 ↗NAcompleted

Vascular Effect of Tibolone Versus Placebo (Brachial Artery)

Flow-mediated Dilation of the Brachial Artery

Enrolment: 60 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29582398 ↗2018Reported benefit

The Synthetic Steroid Tibolone Decreases Reactive Gliosis and Neuronal Death in the Cerebral Cortex of Female Mice After a Stab Wound Injury.

MouseTBIPenetrating / ballisticC57BLFemaleOutcomes assessed 7 days after stab wound injury

Model: Stab wound injury to the cerebral cortex

By 7 days after stab wound brain injury, tibolone reduced the number of GFAP-positive astrocytes, Iba1-positive microglia and reactive-phenotype microglia, and reduced neuronal loss near the wound, compared with vehicle-injected animals.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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