The human natural killer-1 (HNK-1) glycan mimetic ursolic acid promotes functional recovery after spinal cord injury in mouse.
MouseSpinal cord injuryUnspecifiedC57BL/6FemaleOralFirst dose 1 hour after spinal cord injury
Model: Spinal cord injury in mouse; specific injury method not stated in the abstract
Oral ursolic acid started 1 hour after injury and continued daily for 6 weeks improved regaining of motor function and axonal regrowth, decreased astrogliosis, lowered proinflammatory IL-6 and TNF-alpha in the acute phase, and activated MAPK and PI3K/Akt/mTOR signalling in the injured spinal cord.
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