Wnt-Responsive Odontoblasts Secrete New Dentin after Superficial Tooth Injury.
MouseOtherTamoxifen-inducible Axin2 CreERT2; R26R reporter strainApplied to the injured dentin surface, passing through dentinal tubules into the pulp
Model: Two acute molar trauma models: pulp exposure to the oral cavity, and a superficial dentin injury leaving the pulp unexposed
After pulp exposure, cell death was extensive and repair initiated from surviving pulp cells and, to a lesser extent, surviving odontoblasts. After superficial dentin injury the pulp remained vital and innervated, primary odontoblasts upregulated HIF1-alpha and the mineralisation rate increased sig…
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