A Phase 1b/2a Safety Evaluation of ART352-L (liposomal L-WNT3A) in Subjects Undergoing Posterolateral Spinal Fusion
Degenerative Spondylolisthesis
Enrolment: 12 · Results not recorded
Loading the evidence…
Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Degenerative Spondylolisthesis
Enrolment: 12 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Two acute molar trauma models: pulp exposure to the oral cavity, and a superficial dentin injury leaving the pulp unexposed
After pulp exposure, cell death was extensive and repair initiated from surviving pulp cells and, to a lesser extent, surviving odontoblasts. After superficial dentin injury the pulp remained vital and innervated, primary odontoblasts upregulated HIF1-alpha and the mineralisation rate increased sig…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.