Expression of Nrf2-Keap1-ARE signal pathway in traumatic lung injury and functional study.
RatCrushOther / unspecifiedWistarMale30 minutes before traumatic lung injury (pretreatment)
Model: Traumatic lung injury induced by a crushing method
Traumatic lung injury lowered arterial blood gas and superoxide dismutase activity, raised wet to dry ratio, myeloperoxidase, TNF-alpha, IL-2 and Keap1, and lowered Nrf2 and ARE expression. Sulforaphane pretreatment improved arterial blood gas, lowered wet to dry ratio and myeloperoxidase, raised s…
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