Drug · SPLIT ENTITY, handled explicitly. TBE-31: ChEMBL compound_search returned 0 hits, an EXPLICIT NEGATIVE RESULT; the synthetic bis(cyano enone) Nrf2 activator has no ChEMBL entry and no human trial. The human arm resolves instead to CHEMBL48802 SULFORAPHANE, max_phase 3, first_approval NULL, natural_product=true, therapeutic_flag=false, not withdrawn (stereoisomer L-sulforaphane = CHEMBL1627201, max_phase 2). get_mechanism returned 0 records for CHEMBL48802, so the empty moa_list and target are an EXPLICIT NEGATIVE RESULT, not an omission: ChEMBL holds no curated Nrf2/KEAP1 mechanism for sulforaphane despite that being its accepted mode of action. All 10 recorded trials give sulforaphane or broccoli sprout extract; indications are cancer chemoprevention (prostate, pancreas, bladder, melanoma), chronic kidney disease, type 2 diabetes and skin ageing, NONE a trauma indication. NCT03517995 is WITHDRAWN at 0 enrolment and NCT02404428 TERMINATED at n=5.
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
ALL (Acute B-Lymphoblastic Leukemia) · AML (Acute Myelogenous Leukemia · MDS (Myelodysplastic Syndrome)
Enrolment: 36 · Results not recorded
HIV Infections
Enrolment: 20 · Results not recorded
Chronic Kidney Disease Stage 3 · Chronic Kidney Disease Stage 4
Enrolment: 96 · Results not recorded
Diabetes Mellitus, Non-Insulin-Dependent
Enrolment: 103 · Results not recorded
Melanoma
Enrolment: 120 · Results not recorded
Bladder Cancer · Bladder Tumor · Urothelial Carcinoma
Enrolment: 0 · Results not recorded
Autism · Autistic Disorder · Autism Spectrum Disorder · Autistic Behavior
Enrolment: 48 · Results not recorded
Adenocarcinoma of the Prostate · Recurrent Prostate Cancer
Enrolment: 20 · Results not recorded
Prostate Cancer
Enrolment: 18 · Results not recorded
Healthy
Enrolment: 50 · Results not recorded
Prostate Cancer Prevention
Enrolment: 98 · Results not recorded
Pancreatic Ductal Adenocarcinoma
Enrolment: 40 · Results not recorded
Healthy Adults
Enrolment: 25 · Results not recorded
Prostate Cancer
Enrolment: 5 · Results not recorded
Healthy Adult Volunteers
Enrolment: 11 · Results not recorded
Sulforaphane Bioavailability
Enrolment: 16 · Results not recorded
Healthy Volunteers
Enrolment: 6 · Results not recorded
Alzheimer Disease
Enrolment: 160 · Results not recorded
Non-Alcoholic Fatty Liver Disease · Obesity · Metabolic Syndrome
Enrolment: 60 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Chronic solar-simulated ultraviolet radiation exposure of skin (cutaneous tumour formation in mice; acute erythema in healthy human volunteers)
Genetic or pharmacological Nrf2 activation lowered tumour incidence, multiplicity and burden and reduced pro-inflammatory gene expression in mice, and topical sulforaphane reduced ultraviolet-induced erythema in healthy human subjects.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Contusive spinal cord injury
Sulforaphane at 50 mg/kg produced acute and long-term benefit, upregulating the phase 2 antioxidant response at the injury site, decreasing inflammatory messenger RNA including MMP-9, inactivating urinary macrophage migration inhibitory factor tautomerase activity, enhancing hindlimb locomotor func…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Acute carbon monoxide poisoning by exposure to carbon monoxide, with hippocampal neuronal mitochondrial injury and cognitive dysfunction
Carbon monoxide poisoning induced cognitive dysfunction, seriously damaged neuronal mitochondrial ultrastructure, reduced mitochondrial membrane potential and increased Nrf-2 and Trx-1 protein and mRNA. Early administration of middle-dose or high-dose sulphoraphane efficiently improved mitochondria…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Traumatic lung injury induced by a crushing method
Traumatic lung injury lowered arterial blood gas and superoxide dismutase activity, raised wet to dry ratio, myeloperoxidase, TNF-alpha, IL-2 and Keap1, and lowered Nrf2 and ARE expression. Sulforaphane pretreatment improved arterial blood gas, lowered wet to dry ratio and myeloperoxidase, raised s…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
