Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPsigma receptors promotes a beneficial inflammatory response following spinal cord injury.
RatSpinal cord injuryCompressionSprague-Dawley in vivo; C57BL/6 mice and postnatal P1 to P3 Sprague-Dawley pups used in vitroFemalen = 112 adult female Sprague-Dawley rats in total, plus 6 C57BL…Intrathecal, delivered by Alzet osmotic mini-pump via an indwelling catheter with the tip rostral to the lesion10 micrograms of each peptide per day in vivo; 10 micromola…Infusion began immediately after spinal cord injury
Model: Clip-compression spinal cord injury: T6 to T8 laminectomy followed by extradural application of a 35 g aneurysm clip at T7 for 1 min
ILP and ISP shifted the injury response towards an M2 macrophage and regulatory T cell profile with raised IL-10, Arginase-1 and FOXP3 and reduced myeloperoxidase, IL-1beta and IFN-gamma positive effector T cells, but did not alter overall macrophage recruitment, MMP-2 or MMP-9 activity, or GFAP an…
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