THERAPY DOSSIER · th-960187523eef

Intracellular LAR peptide (ILP) and intracellular sigma peptide (ISP), TAT-conjugated functionally blocking peptides

Biologic · Intracellular LAR peptide (ILP) and intracellular sigma peptide (ISP), TAT-conjugated PTPsigma/LAR-blocking peptides.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Intracellular LAR peptide (ILP) and intracellular sigma peptide (ISP), TAT-conjugated PTPsigma/LAR-blocking peptides.
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29558941 ↗2018Mixed findings

Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPsigma receptors promotes a beneficial inflammatory response following spinal cord injury.

RatSpinal cord injuryCompressionSprague-Dawley in vivo; C57BL/6 mice and postnatal P1 to P3 Sprague-Dawley pups used in vitroFemalen = 112 adult female Sprague-Dawley rats in total, plus 6 C57BL…Intrathecal, delivered by Alzet osmotic mini-pump via an indwelling catheter with the tip rostral to the lesion10 micrograms of each peptide per day in vivo; 10 micromola…Infusion began immediately after spinal cord injury

Model: Clip-compression spinal cord injury: T6 to T8 laminectomy followed by extradural application of a 35 g aneurysm clip at T7 for 1 min

ILP and ISP shifted the injury response towards an M2 macrophage and regulatory T cell profile with raised IL-10, Arginase-1 and FOXP3 and reduced myeloperoxidase, IL-1beta and IFN-gamma positive effector T cells, but did not alter overall macrophage recruitment, MMP-2 or MMP-9 activity, or GFAP an…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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