Local Administration of Interleukin-1 Receptor Antagonist Improves Diabetic Wound Healing.
MouseWounddb/db (BKS.Cg-m +/+) diabetic miceMalen = 7 animals, 14 wounds (7 treated and 7 vehicle)Local subcutaneous injection circumferentially into the wound margins70 microlitres containing 5 microlitres anakinra (0.75 mg i…One hour after wounding
Model: Splinted full-thickness excisional wound model with two 6 mm punch biopsy wounds per animal stented with 7 mm silicone splints
Treated wounds were significantly smaller than vehicle-treated wounds at day 7 (p less than 0.02) and day 14 (p less than 0.03), with the day 21 difference not significant, and showed significantly less neutrophil and macrophage infiltration.
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