Effects of aquaporin 4 and inward rectifier potassium channel 4.1 on medullospinal edema after methylprednisolone treatment to suppress acute spinal cord injury in rats.
RatSpinal cord injuryUnspecifiedSprague-DawleyMaleIntravenous, via the tail vein30 mg/kgAt various time points after injury induction
Model: Acute spinal cord injury in rats; the specific injury procedure is not stated in the abstract
Methylprednisolone improved the motor function score and reduced the expression and co-expression of aquaporin 4 and Kir4.1 relative to untreated injury, which the authors interpret as inhibition of medullospinal oedema.
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