Protective effect of tauroursodeoxycholic acid on the autophagy of nerve cells in rats with acute spinal cord injury.
RatSpinal cord injuryUnspecifiedSprague-DawleyMalen = 72 rats in total across sham, saline control and high and l…High and low dose groups; numerical doses not stated in the…
Model: Acute spinal cord injury in rats; the specific injury procedure is not stated in the abstract
Tauroursodeoxycholic acid increased neuronal Beclin-1 and decreased caspase-3 relative to saline controls with no difference between high and low dose, although the abstract also reports that hind limb locomotor scores in the treated groups were decreased, so the functional benefit is unclear.
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