Drug · Unknown
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Primary Biliary Cirrhosis
Enrolment: 216 · Results not recorded
Diabetic Macular Edema (DME)
Enrolment: 69 · Results not recorded
Metabolic Dysfunction-Associated Steatotic Liver Disease Infant Development
Enrolment: 80 · Results not recorded
Transthyretin Amyloidosis
Enrolment: 40 · Results not recorded
Amyotrophic Lateral Sclerosis · ALS
Enrolment: 90 · Results not recorded
Progressive Multiple Sclerosis
Enrolment: 59 · Results not recorded
Asthma
Enrolment: 11 · Results not recorded
Insulin Resistance · Diabetes · Obesity
Enrolment: 101 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Acute spinal cord injury in rats; the specific injury procedure is not stated in the abstract
Tauroursodeoxycholic acid increased neuronal Beclin-1 and decreased caspase-3 relative to saline controls with no difference between high and low dose, although the abstract also reports that hind limb locomotor scores in the treated groups were decreased, so the functional benefit is unclear.
Extraction: extract · Supplied extraction confidence: 0.45. Machine-extracted fields require source verification.
Model: Mouse model of acute neuroinflammation, with parallel in vitro microglial cell cultures; the inflammatory stimulus is not named in the abstract
TUDCA binding to GPBAR1/TGR5 increased intracellular cAMP in microglia, induced anti-inflammatory markers and reduced pro-inflammatory ones. The effect was blocked by small interfering RNA against GPBAR1/TGR5 and by a protein kinase A inhibitor. In the mouse model of acute neuroinflammation TUDCA t…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Modified Allen weight-drop acute spinal cord injury
TUDCA-treated rats had significantly better Tarlov scores and oblique plate performance than DMSO controls from 24 hours after injury (p<0.05). Apoptotic cell ratios were significantly lower in TUDCA-treated rats at 24 hours, 3 days and 5 days (p<0.01) and caspase-12 expression was lower at all thr…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.
