In Vivo Protective Effects of Nootkatone against Particles-Induced Lung Injury Caused by Diesel Exhaust Is Mediated via the NF-kappaB Pathway.
MouseChemical/toxinBALB/cn = Four equal groups, with n equal to 5 per group stated for t…Oral gavage90 mg/kg, selected from pilot experiments against 10 and 30…1 hour before instillation
Model: Diesel exhaust particle-induced lung injury by intratracheal instillation of 30 micrograms per mouse of diesel exhaust particles (SRM 2975) suspended in sterile saline with 0.01% Tween 80, in 100 microlitres, under sodium pentobarbital 60 mg/kg intraperitoneally
Nootkatone pretreatment prevented the particle-induced rise in airway resistance, lavage cell and neutrophil counts, 8-isoprostane, TNF-alpha, DNA damage, cleaved caspase-3 and NF-kappaB, and prevented the fall in glutathione and total nitric oxide.
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