THERAPY DOSSIER · th-feddf086462c

Nootkatone, a sesquiterpene constituent of grapefruit

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29495362 ↗2018Reported benefit

In Vivo Protective Effects of Nootkatone against Particles-Induced Lung Injury Caused by Diesel Exhaust Is Mediated via the NF-kappaB Pathway.

MouseChemical/toxinBALB/cn = Four equal groups, with n equal to 5 per group stated for t…Oral gavage90 mg/kg, selected from pilot experiments against 10 and 30…1 hour before instillation

Model: Diesel exhaust particle-induced lung injury by intratracheal instillation of 30 micrograms per mouse of diesel exhaust particles (SRM 2975) suspended in sterile saline with 0.01% Tween 80, in 100 microlitres, under sodium pentobarbital 60 mg/kg intraperitoneally

Nootkatone pretreatment prevented the particle-induced rise in airway resistance, lavage cell and neutrophil counts, 8-isoprostane, TNF-alpha, DNA damage, cleaved caspase-3 and NF-kappaB, and prevented the fall in glutathione and total nitric oxide.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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