Penehyclidine hydrochloride inhibits TLR4 signaling and inflammation, and attenuates blunt chest trauma and hemorrhagic shock-induced acute lung injury in rats.
RatHaemorrhage/shockControlledSprague-DawleyMalen = 30 rats in total, n=10 per group across three groups (sham,…Infusion over 30 min (femoral vein and artery cannulated; specific route not explicitly stated)2 mg/kg30 min before induction of blunt chest trauma (pretreatment)
Model: Blunt chest trauma at fixed chest impact energy of 2.45 J followed by haemorrhagic shock (blood withdrawal to mean arterial pressure 35-40 mmHg maintained 1 h, then resuscitation with shed blood and twice that volume of Ringer's lactate over 1 h); assessed 6 h after challenge
Pretreatment with penehyclidine hydrochloride attenuated haemodynamic deterioration, improved pH, PaO2 and PaO2/FiO2 and lowered PaCO2 and lactate, reduced lung wet/dry ratio and myeloperoxidase activity, lowered the histological injury score from 3.2 to 2.3 relative to untreated injury (sham 0.5),…
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