THERAPY DOSSIER · th-544e4723b64b

Penehyclidine hydrochloride

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL4594416 ↗
ChEMBL max phase: -1 / 4 (development scale, not regulatory approval)
Synonyms: Penehyclidine; Penequine; Penequinine; Penethequinine; M-8218; P8018
Note: Not recorded

Clinical trials 7

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02644876 ↗PHASE4completed

Preventive Effects of Penehyclidine Hydrochloride Inhalation on Postoperative Pulmonary Complications in High-risk Patients

Postoperative Complications

Enrolment: 864 · Results not recorded

NCT03868709 ↗PHASE4completed

Impact of Prophylactic Penehyclidine Hydrochloride Inhalation on Long-term Outcome in High-risk Patients: 3-year Follow-up

Postoperative Complications · Long-term Outcome

Enrolment: 864 · Results not recorded

NCT04054479 ↗PHASE4completed

The Effect of Penehyclidine on Postoperative Nausea and Vomiting After Strabismus Surgery

PONV

Enrolment: 228 · Results not recorded

NCT06624696 ↗PHASE4recruiting

Inhaling Penehyclidine to Prevent Perioperative Respiratory Adverse Events in Children at Risk Undergoing Sevoflurane Anaesthesia

Perioperative Respiratory Adverse Events

Enrolment: 204 · Results not recorded

NCT04454866 ↗NAcompleted

Effects of Penehyclidine in Preventing Postoperative Nausea and Vomiting in Patients Undergoing Bimaxillary Surgery

Postoperative Nausea and Vomiting

Enrolment: 354 · Results not recorded

NCT04112771 ↗Phase not recordedcompleted

Effects of Penehyclidine on Postoperative Nausea and Vomiting in Patients Undergoing Bimaxillary Surgery: A Retrospective Cohort Study

Postoperative Nausea and Vomiting

Enrolment: 243 · Results not recorded

NCT07519226 ↗NAcompleted

Effectiveness and Safety of Penehyclidine Hydrochloride for Improving Microcirculatory Dysfunction in Critically Ill Children

Shock

Enrolment: 98 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29488614 ↗2018Reported benefit

Penehyclidine hydrochloride inhibits TLR4 signaling and inflammation, and attenuates blunt chest trauma and hemorrhagic shock-induced acute lung injury in rats.

RatHaemorrhage/shockControlledSprague-DawleyMalen = 30 rats in total, n=10 per group across three groups (sham,…Infusion over 30 min (femoral vein and artery cannulated; specific route not explicitly stated)2 mg/kg30 min before induction of blunt chest trauma (pretreatment)

Model: Blunt chest trauma at fixed chest impact energy of 2.45 J followed by haemorrhagic shock (blood withdrawal to mean arterial pressure 35-40 mmHg maintained 1 h, then resuscitation with shed blood and twice that volume of Ringer's lactate over 1 h); assessed 6 h after challenge

Pretreatment with penehyclidine hydrochloride attenuated haemodynamic deterioration, improved pH, PaO2 and PaO2/FiO2 and lowered PaCO2 and lactate, reduced lung wet/dry ratio and myeloperoxidase activity, lowered the histological injury score from 3.2 to 2.3 relative to untreated injury (sham 0.5),…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.

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