Melatonin provides protection against heat stroke-induced myocardial injury in male rats.
RatOtherMaleIntravenous3 mg/kgOne hour before heat stress, with an additional dose immediately after heat str…
Model: Heat stroke induced by exposing anaesthetised rats to an ambient temperature of 43 degrees C for 70 min, causing hyperthermia, hypotension and myocardial injury
Pretreatment with melatonin significantly reversed heat stroke-induced myocardial injury, cardiac oxidative stress and cardiac inflammation.
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