beta-Catenin-Dependent Wnt Signaling: A Pathway in Acute Cutaneous Wounding.
MouseWoundWild-type CD-1 and BAT-gal beta-catenin-dependent Wnt reporter micen = n=4 mice per group (8 wounds per group) for the treatment e…Subcutaneous injection at the wound edge60 uL of a 100 ng/mL solution per wound, given as 15 uL int…
Model: 6 mm full-thickness excisional cutaneous wound created by O-ring (splinted) technique to prevent contraction
Daily subcutaneous rmWnt3a accelerated wound closure and re-epithelialisation and raised nuclear beta-catenin, TGF-beta1, type I collagen and FGFR2, but significantly increased scar size at both 5 and 10 days, so faster healing came at the cost of greater scarring.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.