A Phase 1b/2a Safety Evaluation of ART352-L in Subjects Undergoing Posterolateral Spinal Fusion
Degenerative Spondylolisthesis
Enrolment: 12 · Results not recorded
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Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Degenerative Spondylolisthesis
Enrolment: 12 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: 6 mm full-thickness excisional cutaneous wound created by O-ring (splinted) technique to prevent contraction
Daily subcutaneous rmWnt3a accelerated wound closure and re-epithelialisation and raised nuclear beta-catenin, TGF-beta1, type I collagen and FGFR2, but significantly increased scar size at both 5 and 10 days, so faster healing came at the cost of greater scarring.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.