PRECLINICAL PUBLICATION · 2018

Metabolites of Dietary Acteoside: Profiles, Isolation, Identification, and Hepatoprotective Capacities.

Mixed / Endotoxin/LPS

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Acteoside from cistanche tea and its metabolites hydroxytyrosol, 3-hydroxyphenylpropionic acid and caffeic acid

PMID 29478321 ↗2018Reported benefit

Metabolites of Dietary Acteoside: Profiles, Isolation, Identification, and Hepatoprotective Capacities.

MixedEndotoxin/LPS

Model: D-galactosamine and lipopolysaccharide (GalN/LPS) induced acute hepatic injury in mice; acteoside metabolites first profiled and isolated from rat urine after acteoside administration

Acteoside metabolites showed higher hepatoprotective activity than native acteoside; hydroxytyrosol treatment reduced TNF-alpha to 280 +/- 14.3 ng/L compared with 429 +/- 9.20 ng/L in the model group (p<0.01).

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.