Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury.
RatSpinal cord injuryCompressionSprague-DawleyFemalen = 120 rats in total; n=5 per group stated for the antibody de…Subcutaneous, via implanted osmotic mini-pump (systemic)2 ug/dayApproximately 30 min after spinal cord injury
Model: Moderately severe compressive spinal cord injury; laminectomy at T6-T8 and a 35 g aneurysm clip applied for 1 min at T7
Systemic Nrg-1 started 30 min after injury shifted the immune response towards a regulatory, pro-regenerative profile, increasing M2 macrophages, IL-10-producing M2 cells, Treg and Breg populations and IL-10, while reducing effector T cells, IFN-gamma, IL-6, NFkBIZ, several chemokines and IgG/IgM d…
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