Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Chronic Heart Failure
Enrolment: 146 · Results not recorded
Chronic Systolic Heart Failure
Enrolment: 202 · Results not recorded
Chronic Heart Failure
Enrolment: 679 · Results not recorded
Chronic Heart Failure
Enrolment: 67 · Results not recorded
Heart Failure
Enrolment: 40 · Results not recorded
Heart Failure With Reduced Ejection Fraction
Enrolment: 14 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Clinically relevant model of severe compressive traumatic spinal cord injury
Neuregulin-1 promoted a neuroprotective inflammatory phenotype, reduced pro-inflammatory mediators and inhibitory chondroitin sulphate proteoglycans, and at 1.5 micrograms/day significantly improved tissue preservation and functional recovery.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Surgically induced acute optic nerve injury with sham-operation controls; outcomes followed at 2 h, 1 d, 2 d, 7 d, 14 d and 28 d
Endogenous NRG-1 expression rose after injury, peaking at 14 d and declining by 28 d. Treatment with 1 microgram and 3 micrograms of recombinant human NRG-1 gave significantly better FVEP-P100 amplitudes than normal saline (all P<0.05), and ganglion cell apoptosis was markedly reduced in NRG-1 trea…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Organophosphate nerve agent intoxication with diisopropylfluorophosphate (DFP) causing delayed neuronal injury and neuroinflammation
DFP caused microglial activation across multiple brain regions and increased mRNA of about 1,300 hippocampal genes at 24 h. NRG-1 suppressed microglial activation and reduced by 50% or more a small fraction of DFP-induced genes, predominantly inflammatory. IL-1beta and IL-6 mRNA increases were sign…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Moderately severe compressive spinal cord injury; laminectomy at T6-T8 and a 35 g aneurysm clip applied for 1 min at T7
Systemic Nrg-1 started 30 min after injury shifted the immune response towards a regulatory, pro-regenerative profile, increasing M2 macrophages, IL-10-producing M2 cells, Treg and Breg populations and IL-10, while reducing effector T cells, IFN-gamma, IL-6, NFkBIZ, several chemokines and IgG/IgM d…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
