ERK1/2/mTOR/Stat3 pathway-mediated autophagy alleviates traumatic brain injury-induced acute lung injury.
RatTBIUnspecifiedSprague-DawleyMalePreconditioning before the traumatic brain injury challenge
Model: Traumatic brain injury in rats with secondary acute lung injury; specific impact model not described in the abstract
Enhancing autophagy with rapamycin suppressed apoptosis, inflammation and oxidative stress in lung tissue and improved pulmonary barrier function, oxygenation and static compliance, whereas inhibiting autophagy with 3-methyladenine aggravated these changes.
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