Granulocyte Colony-Stimulating Factor Combined with Methylprednisolone Improves Functional Outcomes in Rats with Experimental Acute Spinal Cord Injury.
RatSpinal cord injuryContusionWistarMalen = 40 rats randomised 1:1:1:1 with 10 per group; 8 excluded (2…G-CSF subcutaneous; methylprednisolone intravenousG-CSF 15 mcg/kg; methylprednisolone 30 mg/kgG-CSF from the moment of injury; methylprednisolone at 10 min, 6 h and 24 h aft…
Model: Laminectomy with moderate contusion spinal cord injury at T10 using an NYU impactor, 10 g rod dropped from 12.5 mm, compressing the cord for 15 s; follow-up to 42 days
The combination of G-CSF and methylprednisolone produced greater locomotor recovery than either agent alone or no treatment from day 14 onwards, with a 5.44 point BBB advantage over control at day 42 (p<0.001), and synergistic histological improvement in hyperaemia and cellular infiltration. Motor…
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